MELATONIN AND MISCARRIAGE

Spontaneous abortions (abortion up to 22 weeks of gestation since the last menstrual cycle or with a fetal weight less than 500.0 g) occur in 15-20% total number registered pregnancies. The incidence miscarriages increases 15% women under 25 and 35% more over 38. Causes can be divided into two categories: those which associated chromosomal abnormalities disruption intrauterine environment.Some studies have shown infl uence systematic placental oxidative stress pathophysiology abortion repeated «stop» pregnancy. Lack antioxidant protection leads recurrent abortions. Membranes’ damages production lipid peroxides, are induced by reactive oxygen species (ROS), as well due certain disorders disorganization, immediately cause abortion. There versions that pineal insuffi ciency may spontaneous abortions, even cases where there no structural uterus. This hypothesis is based on fact melatonin strong binds free radicals its concentration normally signifi cantly during pregnancy pinealectomy rats frequency increases. Melatonin has an immunomodulatory eff ect. It stimulates secretion progesterone, reduces degree uterine contraction prevents immunological rejection trophoblast, inhibits synthesis prostaglandins, potentially induce contractions. Pinealectomy cant reduction circulating blood level rats.